IS Great Eyesight All About Genetics?

Eyesight refers to the capability of an individual to view things. The eyes collect the light from an object that is processed by the brain. The retina is a light-responsive layer that acts as a screen located at the back of each eye. It has photosensitive cells that are responsible for the transfer of information collected from the light to the brain through the optic nerve. If the image constituted on the retinal layer is clear, then the person has a good eyesight.
Maybe you remember an exercise in biology class about dominant and recessive genes in eye color, which allowed you to link your parents’ and grandparents’ eye colors to your own. Are other characteristics, such as nearsightedness or astigmatism, the result of genetics as well?
Many Eye Conditions Are Inherited

The most common eye disorder is refractive error, in which the shape of the eye prevents light from being focused correctly on the retina. Refractive errors include nearsightedness, farsightedness and astigmatism. A research study in 2013 by Nature Genetics, in which scientists analyzed the data from 32 previous studies, discovered at least 24 new genes associated with refractive error, adding them to the two already known.

Here are some of the more common eye conditions that are at least partially due to genetics:

Astigmatism:

In a study of 500 sets of twins, British scientists at the Twin Research Unit at St. Thomas Hospital found that heredity is responsible for 50% of cases of astigmatism, in which the shape of the eye deviates from the ideal and cannot reflect light to the retina properly.

Cataracts:

Cataracts develop over time, due to aging, injury, diabetes or past surgery. Some are related to inherited genetic disorders that increase a person’s risk. Intense exposure to ultraviolet rays may increase their development.

Color blindness:

Color blindness, which is the inability to tell the differences between certain colors, is primarily caused by a defective chromosome. This is more common in males than in females.
Dry eye: Dry eye syndrome can be caused by environmental factors, both in the short- and long-term, as well as by aging, smoking, and Sjorgren’s syndrome. However, a 2014 study of nearly 4,000 sets of female twins by Nature Genetics found that genes had a 30% to 40% impact on whether an individual would be affected.

Farsightedness (hyperopia):

Farsightedness is one of the eye conditions in the category of refractive error. Researchers now have evidence that that it is among the conditions that are genetically determined.
Glaucoma: If you have a family history of primary open-angle glaucoma, the most common kind, you are four to nine times more likely to get it than someone without that family history. There are forms of pediatric glaucoma, however, that are not inherited but instead caused by injury, surgery or another condition.

Macular degeneration:

As the leading cause of vision loss, happens when the central part of the retina begins to deteriorate. It appears to be inherited in a large percentage of cases, and researchers are beginning to identify the genes involved.

Nearsightedness (myopia):

Recent research says that if neither of your parents is nearsighted, you have only about a 2.5% chance of being nearsighted. If one of your parents is, your chances increase to about 20%; if both of your parents are, your chances jump to about 33%, or 1 in 3.

Retinitis Pigmentosa:

A group of related, inherited disorders that can cause night blindness and gradual loss of vision.

Some eye conditions are affected by what happens in your life, such as the environmental elements to which you are exposed, whether you smoke, or whether you are overweight. Dry eye syndrome, for example, can be exacerbated by living in the desert.

Gender Differences in Eye Conditions

Although color blindness affects more males than females, the reverse is true for eye conditions like cataracts and macular degeneration. The American Foundation for the Blind’s Women’s Eye Health Task Force says that nearly two-thirds of all visually impaired or blind people are women. One reason is that many eye diseases are age-related, and women tend to live longer than men.

Other conditions, such as dry eye syndrome, are affected by hormones. And women tend to have more autoimmune disorders than men, which often affect vision.

Less Common Eye Disorders

There are some less common eye disorders and conditions that are inherited. Among them are:

Achromatopsia: Affects a person’s ability to see color at all
Albinism: The level of pigment in a person’s skin, eyes and hair is not typical
Choroideremia: Affects blood supply to the retina
Cone-rod dystrophy: Causes deterioration of cells in the retina
Corneal dystrophies: Corneas lose their clarity and become cloudy
Keratoconus: Thins the cornea and causes it to bulge outward over time
Late-Onset Retinal Degeneration: Has some similarities to macular degeneration, but also affects peripheral vision
Retinoblastoma: A malignant tumor in the eye, primarily in young children
Stargardt’s Disease: Comprises the central vision of the eye and can cause blind spots, decreased sharpness and decreased color vision.

Sources:

  1. What is eyesight ?
  2. Types of Vision

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At Golden Eye Optometry, we view good vision care as front line protection at every age. A routine eye exam can detect more than poor vision. It can shed early light on glaucoma, macular degeneration, cataracts and diabetes.

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